松永講師が共著者になっている論文がオンラインで公開されました（2017年3月15日）。
Article title: A polymorphism of serotonin 2A receptor (5-HT2AR) influences delay discounting
Journal title: Personality and Individual Differences
Authors: Keiko Ishii, Masahiro Matsunaga, Yasuki Noguchi, Hidenori Yamasue, Misaki Ochi, Yohsuke Ohtsubo
DOI information: 10.1016/j.paid.2017.03.011
この研究では、セロトニン２A受容体遺伝子多型と、衝動性の指標のひとつである、時間割引率との関連を調べています。
【Abstract】
The present study investigated the association between a polymorphism of the serotonin 2A receptor (5-HT2AR) gene and the form of impulsive choice known as delay discounting. Using a hypothetical situation, we asked Japanese participants to choose between receiving (or paying) a different amount of money immediately or with a specified delay (one week, two weeks, one month, six months, one year, five years, or 25 years), and estimated the parameters of intertemporal choice models (exponential, hyperbolic, hyperbolic with exponent, and quasi-hyperbolic). Regardless of the genotypes, the hyperbolic with exponent model, which always indicated minimum AICc (Akaike Information Criterion with small sample correction), fitted better the observed data than the other models. Future gains were discounted more steeply than future losses. Moreover, as expected, individuals with the AA genotype of the 5-HT2AR A-1438G polymorphism discounted the future more steeply than did individuals with the GG genotype, although this effect was limited to only gains. The findings implied individual differences based on the A-1438G polymorphism in the modulation of serotonin in the reward valuation underlying delay discounting.