Authors: Bo Zhang, Joanna E. Cohen, Susan J. Bondy, and Peter Selby.
Journal: American Journal of Epidemiology. March 3, 2015.
In the present study, we examined the association between duration of nicotine replacement therapy (NRT) use
and smoking cessation using data from the Ontario Tobacco Survey longitudinal study (3 waves of data collected
between July 2005 and December 2009).We used logistic regression with generalized estimating equations to examine
the association between NRT use (any use and <4 weeks, 4.0–7.9 weeks, 8.0–11.9 weeks, and ≥12 weeks
of use compared with nonuse) and quitting smoking (≥1 month). Using NRT was not associated with quitting when
use duration was not taken into account (adjusted odds ratio (OR) = 1.08, 95% confidence interval (CI): 0.86, 1.35).
Compared with abstaining from NRT when attempting to quit smoking, using NRT for less than 4 weeks was associated
with a lower likelihood of quitting (adjusted OR = 0.51, 95% CI: 0.38, 0.67); however, using NRT for 4 weeks
or longer was associated with a higher likelihood of cessation (for 4.0–7.9 weeks of NRT use, adjusted OR = 2.26,
95% CI: 1.58, 3.22; for 8.0–11.9 weeks of NRT use, adjusted OR = 3.84, 95% CI: 2.24, 6.58; and for ≥12 weeks of
NRT use, adjusted OR = 2.80, 95% CI: 1.70, 4.61). Thus, use of NRT for less than 4 weeks was associated with
reduced likelihood of cessation, whereas NRT use for longer periods of timewas associated with a higher likelihood